Sermorelin
Stimulates the pituitary GHRH receptor to increase endogenous growth hormone signaling and support age-related decline in the GH/IGF-1 axis.
View medication pageTherapy Hub
Hormone Optimization
Hormone optimization therapies are designed to support signaling pathways that influence body composition, recovery, mood, and overall physiologic function. In this category, the focus is on compounds that interact with neuroendocrine pathways such as the growth hormone axis and oxytocin signaling, which may affect stress regulation, social bonding, and broader hormonal balance under prescriber supervision.
Available Medications
Each medication below is grouped here because its mechanism, clinical use, or published literature helps explain why it fits this therapy category.
Oxytocin
A neuropeptide hormone studied for effects on social bonding, stress signaling, and select neuroendocrine pathways relevant to hormone-focused care.
View medication pageMore Medications Available
This is not a comprehensive list of our available medications. We have what you need.
Contact us for moreEstradiol Patch
Systemic estradiol delivered transdermally for individualized menopausal hormone therapy support.
View medication page
Estradiol Pill
Oral systemic estradiol protocol options for individualized symptom management.
View medication page
Estradiol Gel
Daily topical systemic estradiol option titrated by symptom burden and tolerability.
View medication page
Micronized Progesterone
Progesterone support commonly paired with systemic estradiol for endometrial protection and regimen stability.
View medication page
Estradiol Vaginal Cream 0.03%
Localized vaginal estradiol support for GSM-related tissue symptoms and comfort.
View medication page
Estradiol Vaginal Tablets / Suppository
Localized low-dose vaginal estradiol support for atrophy-related symptoms.
View medication page
Injectable Testosterone Cypionate
Individualized testosterone injection protocols with symptom- and lab-guided titration.
View medication page
Transdermal Testosterone Cream
Daily testosterone cream protocol using pump-based titration and monitoring.
View medication page
References
Studies, data, and supporting evidence
These references support the positioning statements used on this therapy hub. They are intended as educational source material for patients and prescribers, not as a substitute for individualized medical judgment.
Effects of Human Growth Hormone in Men over 60 Years Old
Classic trial showing growth hormone replacement increased lean body mass and skin thickness while reducing adipose tissue in older men, supporting the relevance of the GH axis in age-related physiologic decline.
PubMed →The 2022 Hormone Therapy Position Statement of The North American Menopause Society
NAMS states that hormone therapy remains the most effective treatment for vasomotor symptoms, with individualized choice of dose, route, and regimen, and that women with a uterus using systemic estrogen generally need endometrial protection.
PubMed →Estradiol Transdermal System Drug Label
The U.S. label describes estradiol patch use for menopausal vasomotor symptoms and includes application instructions that align with routine transdermal estradiol practice.
Full Text →The Impact of Micronized Progesterone on the Endometrium: A Systematic Review
This review supports oral micronized progesterone as an endometrial-protective partner to systemic estrogen when used in evidence-based sequential regimens.
PubMed →Global Consensus Position Statement on the Use of Testosterone Therapy for Women
The consensus states that the only evidence-based indication for testosterone therapy in women is hypoactive sexual desire disorder, supporting careful and limited hormone-optimization positioning.
Full Text →ISSWSH Clinical Practice Guideline for the Use of Systemic Testosterone for HSDD in Women
ISSWSH provides practical guidance on patient selection, dosing, laboratory monitoring, and follow-up for systemic testosterone use in women with HSDD.
PubMed →