Micronized Progesterone — Endometrial Protection and Symptom Support
An oral progesterone option commonly paired with systemic estradiol when uterine protection is needed and also used in selected women for sleep, bleeding-pattern, or anxiety-related symptom support.
Micronized Progesterone
A bioidentical progesterone option used for endometrial protection with systemic estrogen and, in some patients, for regimen stability or bedtime symptom support.
Cyclical or Continuous
The regimen can be cyclical or continuous depending on menopausal stage, bleeding goals, tolerance, and the overall HRT plan.
| Approach | Protocol | Who It Often Fits |
|---|---|---|
| Cyclical | 200 mg nightly for 12 days of the month | Perimenopause, early postmenopause, or women wanting predictable withdrawal bleeding |
| Continuous | 100 mg to 200 mg nightly | Postmenopause, long-term endometrial protection, and women preferring a stable regimen |
Often taken at bedtime because drowsiness can occur.
- Women using systemic estradiol with an intact uterus generally require progesterone support unless another form of endometrial protection is in place.
- Cyclical regimens may better fit women with ongoing endogenous estrogen production or those who want predictable bleeding.
- Continuous regimens are common after menopause for long-term regimen stability.
- Nighttime dosing may be better tolerated because sedation or dizziness can occur.
Progesterone opposes estrogen’s proliferative effect on the endometrium and helps reduce the risk of endometrial hyperplasia when systemic estrogen is used in women with a uterus.
- Peanut allergy when the capsule formulation contains peanut oil
- Undiagnosed abnormal genital bleeding
- Known, suspected, or history of breast cancer where progesterone is contraindicated
- Active or prior DVT, PE, arterial thromboembolic disease, or known liver disease
- Known or suspected pregnancy
Common adverse effects: Drowsiness, dizziness, breast tenderness, bloating, and mood or bleeding-pattern changes may occur.
- Store at controlled room temperature in the original container.
- Take at bedtime if the regimen is likely to cause drowsiness.
- The medicine should be fine for 5 days from the shipping date at temperatures up to 105 degrees Fahrenheit.
Why do I need progesterone with estrogen?
With a uterus present, progesterone helps protect the endometrium when systemic estrogen is used.
Why is it often taken at night?
Some women experience drowsiness or dizziness, so bedtime dosing is common.
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