NAD+
Central to cellular energy production, mitochondrial function, and DNA repair pathways that decline with age.
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Longevity
Longevity-focused therapies are generally positioned around cellular resilience, energy metabolism, and biologic pathways that tend to decline with age. This hub highlights medications commonly discussed in age-management settings because they relate to NAD+ biology or the growth hormone/IGF-1 axis, both of which are frequently tied to mitochondrial function, DNA repair, recovery, and healthy aging conversations.
Available Medications
Each medication below is grouped here because its mechanism, clinical use, or published literature helps explain why it fits this therapy category.
Sermorelin
Supports the GH/IGF-1 axis, which commonly declines with aging and is often discussed in age-management protocols.
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This is not a comprehensive list of our available medications. We have what you need.
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Studies, data, and supporting evidence
These references support the positioning statements used on this therapy hub. They are intended as educational source material for patients and prescribers, not as a substitute for individualized medical judgment.
NAD+ in Brain Aging and Neurodegenerative Disorders
Review explaining how NAD+ augmentation can restore mitochondrial function and bioenergetics, making it one of the core mechanistic references behind longevity positioning.
Full Text →Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline Across Disease Contexts
Review summarizing evidence that NAD+ precursors are being studied to preserve neuronal energy metabolism and cognition, although clinical outcome data remain early.
Full Text →Dietary Supplementation With NAD+-Boosting Compounds in Humans
Human-focused review showing strong mechanistic interest in NAD+-boosting compounds for healthy aging while noting that clinical benefits are not yet settled across all endpoints.
Full Text →The Safety and Efficacy of Growth Hormone Secretagogues
Review connecting GH secretagogue use with lean mass, fat-free mass, and sleep-related benefits, which helps explain why sermorelin is often grouped into longevity or age-management programs.
Full Text →Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency?
Supports sermorelin's age-related positioning through endogenous GH stimulation rather than exogenous GH replacement.
Full Text →Evidence strength is not identical across all therapies. Some placements are supported by FDA labeling or landmark randomized trials, while others rely more heavily on mechanistic, adjunctive, or early-stage literature and should be framed accordingly.