Estradiol Vaginal Tablets / Suppository — Local Estrogen Tissue Support

• Designed for local GSM symptoms such as dryness, burning, irritation, and dyspareunia.
• Low-dose vaginal estradiol is often chosen when genitourinary symptoms predominate.
• Although local delivery is the goal, systemic absorption warnings still warrant consideration.
• Monitor for vaginal bleeding, irritation, or persistent symptoms that need reassessment.

Localized estradiol supports the vaginal epithelium and surrounding tissues, improving lubrication, epithelial thickness, elasticity, and comfort.

• Undiagnosed abnormal genital bleeding
• Breast cancer or estrogen-dependent neoplasia where estrogen is contraindicated
• Active or prior DVT, PE, stroke, or MI where estrogen is contraindicated
• Hepatic impairment, thrombophilic disorders, or hypersensitivity

Common adverse effects: Back pain, pruritus, mycotic symptoms, diarrhea, or local irritation are reported with approved vaginal estradiol inserts.

• Store at controlled room temperature in the original package.
• Use the supplied applicator if the formulation is packaged with one, or follow compounding instructions for suppository insertion.
• The medicine should be fine for 5 days from the shipping date at temperatures up to 105 degrees Fahrenheit.

How are these different from cream?

Tablets or suppositories are localized inserts and may be preferred when a lower-volume vaginal option is desired.

Will I use them every day forever?

Most protocols use a daily loading phase followed by lower-frequency maintenance.