Estradiol Gel — Systemic Estrogen in a Daily Topical Format
A daily transdermal estradiol gel option for individualized menopausal hormone therapy, offering systemic delivery without an oral tablet or patch format.
Estradiol Gel
A daily transdermal estrogen approach that can be titrated by symptom burden and applied directly to the skin for systemic absorption.
Application Guidance
Apply to the thigh and allow the gel to dry before covering the area. Avoid transfer to others and wash hands after application.
| Symptom Burden | Dose | Frequency | Notes |
|---|---|---|---|
| Mild symptoms | 0.25 mg | Daily | Conservative starting dose |
| Moderate symptoms | 0.5 mg | Daily | Common mid-range protocol |
| Severe symptoms | 1 to 1.25 mg | Daily | Titrate to clinical response |
Apply to the thigh and allow to dry. Women with a uterus generally require progesterone or equivalent endometrial protection when using systemic estradiol.
- Gel offers systemic estrogen support through skin absorption.
- Daily adherence and proper application technique matter for consistent delivery.
- Hands should be washed after use, and contact transfer to other people should be avoided until dry.
- Route selection should reflect symptoms, adherence, preference, and risk profile.
Estradiol gel delivers estrogen through the skin into the systemic circulation, helping stabilize estrogen-deficiency symptoms associated with menopause.
- Undiagnosed abnormal genital bleeding
- Known or suspected estrogen-dependent malignancy where estrogen is contraindicated
- Active or prior DVT, PE, stroke, MI, or thrombophilic disorder
- Hepatic impairment or hypersensitivity to estradiol or formulation components
- Store at controlled room temperature and follow labeled pharmacy instructions.
- Allow the application site to dry before dressing and avoid washing the area immediately after application.
- Keep away from open flame until dry if directed by the labeled product.
- The medicine should be fine for 5 days from the shipping date at temperatures up to 105 degrees Fahrenheit.
Where do I apply it?
Apply to the thigh as directed and allow the gel to dry before covering the area.
Can it transfer to others?
Potential transfer risk is reduced by washing hands after application and letting the gel dry completely.
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Fax completed forms to 385-855-1221 or email pharmacy@genesiscompounding.com